The Teratogenic effect of SSRI’s including Citalopram.

Back to the problem of depressants/antidepressants in pregnancy…

This morning I came across a Freedom Of Information e-mail that I had received from the IMB. It was a copy of the Adverse Reactions Reports (ADR’s) relating to Cipramil. I noticed that there was a intrauterine (inside the womb) baby death reported. The death of this baby was  attributed to “exposure to Cipramil during pregnancy.”

Teratogen; An agent, such as a virus, a drug, or radiation, that can cause malformations or functional damage to an embryo or a fetus.

In Ireland women get very little warning about the teratogenic effect of these drugs. Psychiatrists and GP’s seem reluctant to voice their opinion one way or the other. Whether this is because they don’t want to bite the hand that feeds them or because they believe the drug company spiel is anyone’s guess. Either way, spouting about the benefit/risk conundrum is clearly a get-out clause while in the meantime babies are dying.

In 2010 there was a Case in the High Court, where a little girl’s parents alleged that the disabilities she was born with, were caused by prescription drugs taken by her mother during pregnancy. The Case was settled without admission of liability for €500,000. Article.

I’m not an expert so can only give my opinion but Professor Healy is, so here is what he says: “In the case of the SSRIs as the evidence mounts that these drugs cause birth defects, doubling the rate of major malformations, doubling the rate of miscarriage, increasing rates of voluntary terminations and more than likely leading to learning disabilities/autism in a significant number of children born to mothers on these treatments, we have nevertheless a mounting use of these drugs.”

 

 

 

Here is an excerpt from Professor Healy’s talk “The Cardinals Of Psychiatry” Full Paper here.

Final Acts of the Tragedy

We are facing a true tragedy – a system put in place with the best of intentions to prevent injuries from drugs in general but symbolized in particular by injuries to babies in utero is now leading to just the outcomes it sought to avoid.

In the case of the SSRIs as the evidence mounts that these drugs cause birth defects, doubling the rate of major malformations, doubling the rate of miscarriage, increasing rates of voluntary terminations and more than likely leading to learning disabilities/autism in a significant number of children born to mothers on these treatments, we have nevertheless a mounting use of these drugs.  Where antidepressants were once used rarely in pregnancy they are now among the most commonly used drugs – up to 15% of pregnant women. 

This use is actively promoted by our Cardinals, who collectively make it almost impossible for articles to get published drawing attention to the issues. It is a world where articles can only get published in Vogue or other such outlets – outlining the case of Gina Fromm who for instance when she became pregnant in 2004, did a range of things that few women would have done in 1962 – she took cold rather than hot showers in case she might harm her baby, stopped eating yoghurts and incinerated any chicken because of the risk of bacteria from listeria to salmonella. She balked at taking prenatal vitamins, though she had been taking Paxil following a fleeting episode of anxiety.  She continued to take it through her pregnancy; she had found stopping difficult and her doctor reassured her it posed no risk to her baby.  On February 2nd 2005 her son Mark was born with congenital heart defects.

……………………………………………

The Death of the baby in the IMB e-mail was associated with Cipramil. We asked Lundbeck if their drug was a Teratogen. Although they seem to admit it, here is a prime example of drug company spiel….

Leonie  Do you think that it’s advisable to virtually bathe foetuses in Serotonin given it is now accepted this family of drugs are firmly associated with birth defects?

 Dr. Madsen  Virtually bathe?

 Leonie   Foetuses in Serotonin – pregnancy.

 Tony   Pregnant women.

 Dr. Madsen  I don’t know what you mean by virtually bathe

 Leonie    I’m talking about anti-depressants are known to cause birth defects.  If you think so, would it not be better if women of child-bearing age were cautioned against, perhaps even contra-indicated from using this drug?  Citalopram or Escitalopram?

 Dr. Madsen   Em, I think in…..

 Leonie   Your views?

 Dr. Madsen  In pregnancy?

 Mr. Schroll   the medicines agency authorities you can see what is in the checks that the Doctors and that is up to them to decide…..

 Leonie   So you are passing the buck back to the Doctor again.

 Mr. Schroll  I think when it’s prescription medication, yes.  If it was eh, eh,

 Leonie   And will they be told that it can harm their unborn baby?

 Mr. Schroll   Sorry?

 Leonie   Will the pregnant woman be told that the drug can, can harm her unborn baby?

 Dr. Madsen  Em, I think em, physicians need to double their efforts to make sure that there is a correct risk versus eh, benefit eh, assessment of the em, of any action.

 Leonie   Is Citalopram and Escitalopram a teratogen?

Dr. Madsen   Em, meaning, what, what, what do you mean?

 Leonie  Can it cause harm to foetuses? Unborn babies.

 Dr. Madsen   Em, obviously, in order to have our compounds approved we have done em, a large number of pre-clinical trials em, and we are constantly monitoring and the eh, while the recommendation I believe throughout, is to be, be extra cautious when administering any eh, medications to pregnant women…

 Leonie  Can it cause harm…..to unborn babies?

 Dr. Madsen   Anything can cause harm, can cause harm in any dose…

 Leonie     So yes it can.

 Dr. Madsen  depending on dose

 Leonie      Yep…………Em, why if it can cause harm, is this not clearly, clearly stated on the packaging and information leaflet?

 Mr. Schroll   Do you talk about the patient leaflet or do you talk about the SPC, the label that the Doctors use in order to prescribe the medication?

 Leonie    I’m talking about a pregnant woman that goes down and gets it in the chemist.  Is it on the patient information leaflet?

 Mr. Schroll   In the patient leaflet it says you have to talk to your Doctor….

 Leonie   And what does it say in the Doctor’s leaflet?

 Mr. Schroll  That he has to be extra cautious.  I think that if you go to the… to, to the Irish home page, I believe it is like that, it’s like that in Denmark and elsewhere.  If you go to the medicines agency authorities

 Leonie   So,

Mr. Schroll    It would be part of the discussion to talk about the risks and the benefits and that would be up to the Doctor.

 Leonie    It would be up to the Doctor to tell them that the drug can harm their unborn baby?

 Mr. Schroll   Eh, now, you’re talking…..

 Leonie   It’s not up to Lundbeck, no?  It’s up to the Doctor to tell the woman that the drug can harm their unborn baby?

 Mr. Schroll   To be cautious, yes, yes.

4 thoughts on “The Teratogenic effect of SSRI’s including Citalopram.

  1. Ha! Leonie you are wonderful.
    I did let out a laugh with reading ‘at any dose’ being followed by ‘dose depending’.
    My Good God, these idiots stumble and struggle on the spot dont they.

    I decided it best to terminate whilst heavily dosed with Efexor xr, although i did not have the brain capacity to think of defection risk and our decision (mine and partners), was actually based on my mental state at that time (prone to aggresive outbursts and/or total despair).

    The truth is sickening isnt it.
    You asking about whether its right to virtually bathe unborn babies in Serotonin and the non understanding of it as a posable question makes me shudder.

    These bastards are definitely not getting it are they, they dont grasp the concept of a tiny growth form with no defence is being systematically abused.

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  2. I’m glad I was able to give you a laugh and am really glad you didn’t terminate yourself on Efexor.
    I’m not quite sure what they thought. I think they actually thought that they could tell me that Shane did not die because of their drug and I would say OH OK and go home!
    It was like talking to dumb and dumber but rest assured, they knew exactly what they were (or were not) saying. At one stage they looked like they wanted to reach across the table and strangle me. The feeling was mutual!
    Leonie

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  3. Mr. Schroll …… you can see what is in the checks that the Doctors ….. and that is up to them to decide …..

    Mr. Schroll …… you can see what is in the checks that the Doctors cash ….. and that is up to them to decide …..

    There, fixed it for you Mr Schroll.

    Lundbeck’s Danish, right?

    How many of those checks are coming out of Ireland’s Treasury?

    And how many More checks for how much more are going to have to come out of Ireland’s Treasury to pay for those birth defect heart operations for at least two more decades IF, the causative agent is withdrawn from the market today?

    And BTW: Was there an acceleration of ‘Mental Health’ concerns in Ireland in the last decade or so, tossing workers onto disability? These drug peddlers have made such a mess of my country, well, look at the charts.

    http://www.esri.ie/irish_economy/

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