Cases, cipramil (celexa) stories,, lundbeck, Our story., psychiatry, Random, Shanes story.

The Pharmaceutical Industry’s Influence in Irish Politics and Medicine.

Enda and James

The pharmaceutical industry has a long and tangled involvement within Irish politics. Besides politics, our medical ‘experts’ have built up their training and expertise while simultaneously having a fundamental collegial relationship with the pharmaceutical industry. Pharma politics may not be news to Americans, Latvians or our British neighbours – but as Ireland is my Country of birth, I claim poetic licence in focusing on my specific geographical area. Corruption within this industry has been widely publicised elsewhere but there seems to be a reticence within the Irish media to report on pharma wrongdoing or the objectivity of the psychiatric expert. My son, a young Irishman, died under the influence of 17 days of Citalopram (an SSRI antidepressant) – manufactured by Lundbeck, prescribed by a doctor, licensed by the Irish Medicine’s Board (henceforth IMB) and protected by the Irish College of Psychiatry (henceforth the College).

Despite much evidence to the contrary, our health Minister James Reilly has been quoted in the media as saying that “SSRIs aren’t addictive and treat depression effectively”. He also denied that GPs are systematically over-prescribing SSRIs.[1] He subsequently managed to ignore two medical experts (David Healy and Declan Gilsenan) who gave testimony in Leinster House that antidepressants were the leading cause of death within the mental health field and were in fact causing hundreds of Irish deaths each year. According to the Irish Pharmaceutical Healthcare Association there are approximately 120 pharmaceutical companies that have plants in Ireland – including 9 of the 10 largest pharmaceutical companies in the world.[2]

Last year the Irish Times reported that the Irish Government ‘came under pressure’ from the larger pharmaceutical firms over the Health Service Executives’ (HSE) decision not to approve new drugs for payment. There was an implied threat that this could ‘have implications for 25,000 jobs and future investment’ – so not surprisingly Enda Kenny and James Reilly backed down. The Times further reported that both had meetings with Abbott Laboratories and Eli Lilly, and further that Enda Kenny attended Eli Lilly’s board dinner at the Old Kinsale golf club in 2011. It is submitted that this relationship is much too close for comfort and therefore not conducive to having the Nation’s best interests at heart. Backing down under pressure from a bullying industry is never a good move, particularly when as a Nation we naturally assume that our Government is in control.

According to Dr David Healy who is regarded as the world leading expert on prescription drugs, antidepressants double the risk of suicide and violence, particularly upon starting, discontinuing and dosage change (up or down). He further stated that “antidepressants now come with black box warnings of suicide and in some jurisdictions such as Canada they come with warnings of violence also. Exactly the same mechanisms that lead to suicides lead to violence. In one case you have violence directed inward and in the other directed outwards. These mechanisms are akathisia, emotional blunting and psychosis.”[3]

The name ‘antidepressant’ itself is pure marketing genius by the pharmaceutical industry. Who would believe that these so-called magic pills can cause death, sometimes self-inflicted and extremely violent? In protecting the medical model, referring to antidepressant-induced suicide, the College stated “Anecdotal cases of suicide sometimes mistakenly attribute these tragic events to the treatment rather than the illness itself”.[4] This is a vastly differing stance compared to the IMB, the European Medicine’s Agency (EMA) and the Food and Drug Administration (FDA). The American regulator FDA slapped a black-box warning on all antidepressants, informing consumers of the increased risk of suicide.[5] The EMA followed suit requiring labelling changes to all antidepressants, again informing consumers of the increased risk of drug-induced suicidality.[6] The IMB is pretty limited in its capacity of protector of Irish citizens, deferring largely to the EMA. Interestingly, the IMB is almost fully funded by the pharmaceutical industry, so the public protector is funded by the very industry that it is supposed to be protecting the Irish people from. It should be noted that peter gøtzsche of the Nordic Cochrane Centre in Copenhagen recently stated that the IMB banned GlaxoSmithKline from claiming that Paroxetine (Seroxat/Paxil) corrects a chemical imbalance.[7] That depression is caused by a ‘chemical imbalance’ is a pharma invention used as a tool to sell antidepressant drugs. That the IMB made an executive decision and actually suppressed GSK or any other pharmaceutical company is the exception rather than the rule.

We don’t have to look too far to see Governmental and pharma influence within the medical industry. The ‘Sherif Sultan Saga’ is a prime example of the bullying and intimidation of a medical professional. Mr Sultan is a consultant in Galway who received an official warning and a gag order from the HSE for speaking out on the dangers of taking statin drugs.[8] This followed the publication of his paper ‘The ugly side of Statins’.[9] Mr Sultan said what David Healy has been saying for a long time, that he and his colleagues “are fed up with trial of organizations to cover up truth about the ugly side of statin because of invested interest and commercial sponsorship.” He also stated that “We are observing the revealing of the ‘utmost medical tragedy’ of all times. It is extraordinary that the healthcare industry has inadvertently induced life-threatening nutrient deficiency in millions of otherwise healthy people.”

Similar to the attempt at suppressing Sherif Sultan, the psychiatric Professors Patricia Casey, University College Dublin, and Ted Dinan, University College Cork, involved themselves not only in my son’s inquest but also with others where antidepressants were implicated. Both had long links to the same pharmaceutical companies who manufactured the implicated drug and both without exception defended the drugs, instead blaming the supposed underlying ‘illnesses’.[10] Both these professors are supposed experts in the psychiatric field and both fiercely defend antidepressants.[11] It is submitted that the objectivity of the expert opinion is paramount, particularly where the law is concerned. As the coronial system is the only Court of law where a deceased’s family can get answers, in cases of drug-induced death, bias or even a perception of bias should automatically render these ‘experts’ excluded from the legal process.

The health of the Irish nation will never be of utmost importance while our medical professionals, the IMB and the Irish Government have a vested interest in upholding the existing ‘pharma funded’ regime. While it seems my son was just a number in the collateral damage of the latter – I urge you to protect your family, start asking questions and stop trusting these dubious so-called professionals.


[7] Peter Gøtzsche ‘Deadly Medicines and Organised Crime’ P. 199

Newspaper and internet articles, Random

Vanessa’s Law – ‘Protecting Canadians from Unsafe Drugs’ (Bill C-17)

Terence young

Terence Young is a Canadian MP whose 15 year old daughter, Vanessa, died from a heart attack due to the heartburn medication Cisapride, marketed as Propulsid.

A month after Vanessa’s death the FDA released a statement stating that Propulsid was being pulled off the market due to the associated risk of serious cardiac arrhythmias and death; here. An Article by ‘Thomas L. Perry’ stated that Vanessa’s father was dumbfounded to read this Los Angeles Times exposé showing that the FDA and the manufacturer had known since 1993, 7 years before Vanessa’s death, that Prepulsid caused cardiac arrhythmias.

Yesterday (6th Dec 2013), the Canadian Minister for Health Rona Ambrose announced that the Canadian government is introducing new patient safety legislation, Vanessa’s Law, providing for the protection of its citizens from unsafe drugs.Vanessa Young Minister Ambrose stated “Today, we have introduced Vanessa’s Law, a law that would protect Canadians and help ensure that no drug that is unsafe is left on store shelves.” The proposed new legislation, if enacted, will enable the Canadian Government to sanction the pharmaceutical industry for selling unsafe products, proposing fines of up to $5 million per day and even imprisonment. It further provides that the Government can compel drug companies to do further testing, to revise their labels and recall dangerous drugs.

Terence Young stated “It is difficult to overstate the impact this bill will have for Canadians who take prescription and over the counter drugs. It represents a quantum leap forward in protecting vulnerable patients and reducing serious adverse drug reactions. It is absolutely necessary to reduce deaths and injuries caused by adverse drug reactions, seventy percent of which are preventable, and will serve Canadians extremely well.”

It remains to be seen whether this bill will be enacted. If so, the Canadian Government will be the first to put their citizens before the very powerful multi-billion dollar pharmaceutical industry. Either way, I foresee strong resistance to this bill, but maybe, just maybe, this is the first major bruise on Pharma’s Achilles’ heel.

In contrast to the latter, the UK Government recently debated the suicide link associated with Roche’s ‘Roaccutane’. Again, two parents had waited 10 years to get this debate to Westminster, this time on the Roaccutane-induced ‘suicide’ of their son following a few short weeks on Roche’s notorious acne drug. Roche pulled this drug off the US market in 2009, but it’s still available in the UK and Ireland. It has been stated that Roaccutane may have caused up to 20,000 deaths. The Westminster talk can be viewed here: approx 16.27 Mins. Caroline Nokes MP looked, to all intents and purposes, like she was sucking a Roaccutane-soaked lemon. I can only hope that the promise to keep talking to these parents was well-intentioned and not just Minister’s puff.

So, the Canadian and UK Government are at least discussing prescription drug induced deaths. The Irish Government are not!

cipramil (celexa) stories,, lundbeck, Our story., psychiatry

LKMC Syndrome.

Lundbeck Killed My Child DisorderSo what’s happening this week in the depressing world of suicide and ‘mind altering drugs’?

The following was meant to be tongue in cheek but actually the subject is too serious and I miss my son too much to make light of this issue.

Did you hear there’s a new syndrome that’s just been confirmed? Yep, LKMS disorder aka ‘Lundbeck Killed My Son’ Disorder. I suppose if I was being fair, it should be called ‘LKMC’ aka ‘Lundbeck killed my Child’ Disorder. There are many of us affected by this virus, although thankfully it isn’t contagious.

It should be noted that LKMC disorder is a global problem, not just restricted to Ireland or the UK. In fact America, New Zealand and China are reporting an ever-increasing rate of suicide. I have previously shown that the unsuspecting Chinese are killing themselves at an alarming rate, most likely due to the relatively new ‘depression’ advertisements, pushed by dubious pharmaceutical companies including Lundbeck, here.

The latest news regarding the DSM-5 is that grief for more than 2 weeks, even after the death of a loved one, can be seen as a symptom of Major Depressive Disorder, here. Considering that Shane is dead almost four years and I can still blubber like a lunatic at the worst possible moments; that surely means I’m decidedly unwell. I wonder if a pill could cure the death of my son? Can they miraculously make him re-appear? Even your toddler’s ‘temper tantrums’ may be diagnosed as an illness under the new and ‘unimproved’ DSM-5 and therefore medicated accordingly.

This week researchers from Duke University reported that antidepressants, including Lundbeck’s Lexapro appears to help prevent a potentially serious stress-related heart condition. You can find the study in ‘The Journal of the American College of Cardiology’ here. I’d list the conflicts of interests but there isn’t enough room on the page. You can access them yourself by clicking the ‘Author Information’. Now you will have to pardon my stupidity here, but surely these researchers know that Lexapro causes heart-attacks and sudden death? The FDA sent out a warning letter to all practitioners advising of the risk of heart problem with Citalopram in August 2011. This was revised in March 2012 to include Escitalopram, which is no surprise as they’re basically the same drug (as found in a Brussel’s Court here).

Lundbeck whose patents (and patience) are running out, have been frantically scrambling around for their next block-buster drug. Vortioxetine aka Brintellix is their latest offering.  Data concerning Vortioxetine efficacy was presented at the 2013 American Psychiatric Association Annual Meeting (APA). 4 trial results were shown, 3 for and 1 against. It’s the 1 against that I would be interested in. Was there any deaths? There was certainly a death in one of the Citalopram trials. Are they going to publish all the Vortioxetine trials as GSK are supposed to be doing? Actually no, ignore that, GSK backtracked on that particular promise!

We will have to wait and see whether Vortioxetine will get a ‘licence to kill’ by the FDA and the EMA, and if so, whether it will add to the growing cases of LKMC disorder.

cipramil (celexa) stories,, lundbeck

Meet Larry..

Larry 1Meet Larry, 63. Larry underwent a ‘triple bypass’ operation last Christmas, which involved spending 26 days in the Mater hospital, Dublin. Open heart surgery is known to be a very serious procedure; not least because the sternum (which is opened during surgery) can take up to 12 weeks to heal. Cardiologists acknowledge that Heart surgery is life-changing, both physically and emotionally.

Larry was a good guy, the eldest of six. He was relaxed, funny, and easy-going, with a wife whom he knew since they were teenagers. He had 4 children and 7 grandchildren who adored him. Following Larry’s triple bypass, as is common following big operations, he started to feel a little down. He was prescribed an antidepressant Lexapro (Lundbeck’s poison and the same drug Shane was prescribed). He took Lexapro as prescribed for about a week. He told his son that his head felt like it was exploding, that it wasn’t in sync with the rest of him and that he was ‘all over the place’.

Larry went back to the doctor and his medication was changed, this time to a newer antidepressant, Valdoxan (AKA Agomelatine, manufactured by Servier) and the Benzodiazepine Xanax, another potentially dangerous drug. Larry was prescribed this drug despite recent reports that Valdoxan is associated with serious hepatotoxicity (liver damage) and that caution is advised when prescribing for overweight/obese patients. I’m sure Larry wouldn’t mind me saying that he was more like Pavarotti than Rudolf Nureyev. Either way, I’m not quite sure why any medical professional would prescribe this drug considering the doubts surrounding its efficacy and the possible dangerous adverse effects. Warning here.

According to Larry’s family, following the later prescription for Valdoxan and Xanax, he became manic, unable to function; the simplest of tasks became mammoth. He behaved bizzarely, for example: he wouldn’t allow his wife out of his sight, insisted on holding her hand at all times, seemingly afraid to let go. This was totally out of character for the usually easy-going Larry. As usual, this change was put down to the after effects and trauma of this huge operation, not the mind-altering drugs which are prescribed to unsuspecting patients, including Larry.

On 27th Febuary 2013, Larry took a rope into the garage of his old family home and less than the required 12 weeks it took for his sternum to heal, this easy going 63 year-old man was dead.

There are 2,370 suicides and 1,539 Cardiac arrests reported as a drug- reaction (of Xanax) in the RxISK website. Valdoxan (Agomelatine) is not on the RxISK website because it is not approved by the FDA in America. This drug has been called ineffective, potentially dangerous and ‘a dog’ and had 3 (acknowledged) suicides in clinical trials, before it was even approved. For more of Valdoxan’s dodgy trials and other dodgy dealings with this IMB approved drug, retired psychiatrist and scientist ‘1 Boring Old Man’ explains it here.

The Valdoxan patient information leaflet (PIL) has the usual IMB inadequate suicide warning, although directed at under 25s:

 A meta-analysis of placebo-controlled clinical trials of antidepressants in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo, in patients less than 25 years old. Close supervision of patients and in particular those at high risk should accompany treatment especially in early treatment and following dose changes. Patients (and caregivers of patients) should be alerted to the need to monitor for any clinical worsening, suicidal behaviour or thoughts and unusual changes in behaviour and to seek medical advice immediately if these symptoms present.

The fact that the so-called psychiatric ‘experts’ in Ireland deny that these drugs can cause suicide, arguably negates the above warning. Even though Larry was aware of Shane’s case and the role that antidepressants played, he, like most people, trusted that the medical professionals knew better.

RIP Larry.

Lexapro PIL

Valdoxan PIL

Xanax PIL

Newspaper and internet articles

A nation of zombies?

mannequinsThis week the  revelation that we are eating horse and pig with our beef burgers has come as a bit of a shock. Although I have to say, surprisingly, it hasn’t come as a huge shock for many, and a commonly held opinion is ‘Ah well, sure if you’re willing to eat parts of a cow, there’s not too much difference’. Surely that is completely missing the point? We are entitled to know exactly what we are buying. Whether we, as consumers, pay 10 euro or 10 cent for a beef burger, it’s supposed to be beef and if we wanted a filly burger, we’d have asked for one! Apart from the fact that if the company who sells the product cannot vouch for the content (and therefore any contagious diseases), it’s false advertising. Vegetarianism is looking increasingly attractive.

It the same with antidepressants. The name itself is false advertising. If I wanted a product which can double  the rate of suicide and cause worsening depression, not to mention heart-attacks and strokes, surely I’d have bought myself a gun? A game of Russian roulette would at least minimise the suffering. Or maybe I wouldn’t do the job properly and end up physically disabled too. Then even worse, I could be forced by the Irish judicial system to roam this world until my ‘natural’, undignified, and painful death, as shown in a recent Irish case. In my opinion, this brave woman is being discriminated against because she is disabled, by the very system which purports to do ‘justice’.

Maybe, as a consumer, I’d be one of the lucky ones, where that antidepressant would do the job which the name implies, and I’d live happily ever after, discarding the drugs after a few months. Then again, I could be the one who can’t get off the drugs, the one who is addicted and any attempt to stop the drug leaves me with debilitating side effects, unable to function, love, or care either way.

Or maybe I’d be on them for life, thinking they’re doing a great job but everyone else is thinking ‘there’s something not quite right’ with Leonie? It’s quite possible that has been said already, but if so, it’s down to life experiences and genetics, not any prescription drug. You know the type though? That woman or man who speaks a little too loud, unaware or uncaring of people around them? The one that isn’t aware of personal or societal boundaries. That woman you meet at the shop who wants a full-blown conversation with you, despite having never met her before? Or the one that always seems to be on a different planet and just that little bit ‘different’? The one who never did illegal drugs, doesn’t drink but yet has slightly slurred speech and a slightly longer reaction time to others.

Over-prescribing and prescribing dangerous medication for every twinge is rampant globally, not just in Ireland. The only winner is the pharmaceutical industry, not the patients or their families. Be informed, read the leaflet, or in the case of the Irish Medicines Board, go to the FDA website where more information is provided. Don’t be turned into a unwitting drug company zombie. Whether this rings a bell or not, the importance of finding a good doctor should never be underestimated.

If your current doctor hasn’t the time to listen, maybe it’s time to find another one!

Irish Times, Assisted suicide case

The Telegraph, Horsemeat in burgers.

EMA, Suicide/Aggression with ssri’s Link 

Antidepressants and Violence; Prof. David Healy et al, here or download here.

Suicidality, Violence and Mania Caused by SSRIs; Dr Peter R Breggin here.

Drugs associated with violence. Here.

Newspaper and internet articles, Random

GlaxoSmithKline awarding the Irish media? No thanks!

‘RTE Radio 1’ has a Facebook page which proudly states “We’re delighted that RTÉ took home three awards at this year’s GSK Irish Medical Media Awards.” Two of the awards were won for documentaries, one on depression and another for clinical trials involving children.

Seriously though? That’s GSK; GlaxoSmithkline! Why is a pharmaceutical company (which has consistently been proven corrupt), sponsoring Ireland’s ‘Medical Media Awards’ and why is this acceptable?

Here’s an Irish article from 1998 which refers to Seroxat/Paxil called ‘Pill to melt shyness‘. The article states that people suffering from this ‘crippling’ illness ‘aren’t aware that they have such a condition’ and that ‘By itself, social phobia doesn’t bring on suicide but combined with other psychiatric illnesses victims are six times more likely than the general population to kill themselves‘. OK, so these poor unfortunate sufferers may go on to kill themselves from shyness and taking Seroxat should fix the problem? The article further states that the time this illness or ‘social phobia’ usually strikes is between the ages of 14 and 16 years old. Hang on a sec!! Panorama did a series of TV documentaries ‘outing’ GSK and the notorious Seroxat. They revealed, among lots of corrupt practices, that in one of GSK’s drug trials, adolescents were six times more likely to become suicidal after taking it. So the illness increases the risk of suicide by 6% and the cure by another 6%; a better mathematician than I would tell you, that’s not a good percentage for a so-called cure!

In July of this year GSK were fined $3 billion in the US for, among other things, illegally promoting this drug for children, despite being aware that the same drug could cause these children to kill themselves.

GSK’s ‘Better Together‘ campaign states…” to ensure Irish patients and consumers can get access to the health care they need, GSK recognise that we must work in partnership with Government, policy makers, healthcare professionals, patient and citizen groups.” I bet they do! Also this, “GSK wants to be healthcare partner of choice, valued for our expertise and trusted for our integrity.” What integrity is that exactly?

Ok, forgetting the fact that they have caused numerous ‘Seroxat induced’ deaths in children and adults; maybe it’s the ‘Avandia Scandal‘ integrity they’re talking about? Avandia is the drug that the FDA scientist ‘Dr. David Graham’ said ‘may have caused as many as 100,000 heart attacks, strokes, deaths and cases of heart failure’ before the drug was finally taken off the market. GSK still clung to the mantra the drug was safe though. Never admit anything? Surely GSK is the last company (apart from Lundbeck) that the Irish Medical Media should associate with? In my humble opinion, the medical media, whose job it is to investigate, should have done a little research into the company who was sponsoring these awards. Then they may have had some integrity of their own and told GSK to stick their awards where the sun doesn’t shine!

https://leoniefennell.wordpress.com/2012/07/04/irish-reports-on-gsks-fraudulent-marketing/

http://www.nytimes.com/2012/07/03/business/glaxosmithkline-agrees-to-pay-3-billion-in-fraud-settlement.html?pagewanted=all

http://fiddaman.blogspot.ie/2012/10/gsk-flying-flag-of-hypocrisy.html

lundbeck, Newspaper and internet articles

Mother Says Lundbeck’s Seizure Drug Blinded Her Son

Another case of Lundbeck’s nonexistent pharmacovigilence? The ‘failure to warn’ here is criminal, but not surprising.

I can understand Lundbeck doing this to a child considering its track record for killing and maiming children, but I can’t understand how the FDA could licence an addictive benzodiazepine (which incidentally can cause  aggression and suicidal thoughts) for children as young as 2.

April 05, 2012

Mother Says Seizure Drug Blinded Her Son

GALVESTON, Texas (CN) – A mother claims in court that Lundbeck Pharmaceuticals’ seizure drug Clobazam blinded her 9-year-old son, made his skin slough off, and filled his mouth with blisters.

Kelly Gutierrez sued Lundbeck LLC, Lundbeck Pharmaceuticals Services LLC and H. Lundbeck, on behalf of her son, L.C., in Federal Court. Lundbeck A/S is a Dutch corporation; the other Lundbeck entities are based in Deerfield Park, Ill. “Clobazam is marketed under the names ONFI and Frisium by defendants,” according to the complaint.

According to the complaint, ONFI is a prescription medicine used along with other medicines to treat seizures associated with Lennox-Gastaut syndrome in people 2 years old or older. ONFI was approved for use in the United States in October 2011. Gutierrez says doctors prescribed ONFI to her son to treat his epilepsy/seizure disorder, and the drug was initially successful in controlling his seizures. “However, 3 weeks into the treatment, L.G.’s mother noticed a change in the color of the pigmentation in L.G.’s eyes,” the complaint states. “Several days later, after what looked like chicken pox developed all over his body, L.G. began having difficulty breathing and was taken to the emergency room.

“The next day, L.G.’s mouth filled with severe blisters. Just days later, L.G.’s condition had worsened to the point that he was air lifted to Shriner’s Burn Hospital in Galveston, where he was placed in the intensive care unit.”The surgeries began the next day. So far, L.G. has had four surgeries, including pig skin grafts to replace all the skin that has sloughed off. He now has stitches in his eyes, is blind, horribly disfigured, and suffers horrific pain on a daily basis. “Due to use of ONFI, L.G. developed Steven[s] Johnson Syndrome (SJS) that escalated to TENS (toxic epidermal necrolysis).

“SJS is a rare, serious disorder in which skin and mucous membranes react severely to a medication. SJS begins with flu-like symptoms, followed by painful red or purplish rash that spreads and blisters causing the human skin to die and shed. SJS is treated as a burn, which is why L.G. is currently being treated at Shriner’s in Galveston. “In December 2011, Defendants completed a study linking the use of Frisium to SJS and TEN. Despite having the information, no such information was passed on to medical professionals who might choose to prescribe ONFI to patients like L.G.” (Parentheses in original.)

Gutierrez seeks punitive damages for product liability, negligence and gross negligence.

She is represented by Anthony Buzbee.

…………………………………………………….

Clobazam Adverse Events

Common adverse effects reported by patients receiving clobazam included somnolence, sedation, fever, drooling, constipation, cough, urinary tract infection, insomnia, aggression, fatigue, upper respiratory tract infection, irritability, vomiting, trouble swallowing, problems with coordination, bronchitis, and pneumonia.

The FDA warns that clobazam may increase the risk for suicidal thoughts or behaviors in a very small number of people. Patients taking antiepileptic drugs should be monitored for depression and unusual changes in mood or behavior. Link.

It’s not the first of Lundbeck’s drugs that can cause blindness in children; https://leoniefennell.wordpress.com/2011/05/31/vigabatrin-sabril-which-can-be-used-in-infants-can-cause-blindness-suicide-ideation-and-aggression/

Random

Vigabatrin/Sabril (which can be used in infants), can cause blindness, suicide ideation and aggression.

Targeting infants now? Leave them alone!!!
 
Last week I came across a blog for pharmaceutical reps and employees, it was called Cafepharma and it allows people employed in the Pharmaceutical industry to post messages on a Message Board. Link. I thought this was an interesting answer to a query posted by a prospective employee of lundbeck…
 
Question.

What’s it like to work for Lundbeck?
Please give me the good, bad, and the ugly. And pleeeeease…no snide remarks like CP posters often give. I’ve been approached to apply for a position (a product that is for intermittent seizures in infants). Anyone have any insight about the company and/or the product’s popularity/pros and cons of promoting it?
Thanks in advance to any serious posters.
 
Answer
Vigabatrin in the product. Serious side effects like making kids go blind. You better go speak with some child neuro`s in your area to get the real info. It is an end of the line product with very limited usage due to severe side effect risks. Be very careful with this company. If you`re asking for anonymous advice, I`d stay clear of it unless you just have been unemployed for a very long time and need a pay check.
 

Vigabatrin:

 
The message board didn’t paint a pretty picture of lundbeck and subsequently I googled lundbeck’s product Vigabatrin, and sure enough it can cause irreversable blindness! It is an anti-epileptic drug that can be prescribed for intermittent seizures in infants. As far as I’m aware, you cant die from epilepsy so why would anyone prescribe this for an infant, when it’s possible that they can end up being blind as well as epileptic? Then if the child is old enough he/she might commit suicide or an act of agression, totally as a side-effect of the drug and the people that are left behind will never be informed of this! Surely there is a better alternative?
 
This is what it says on lundbeck’s own website… “Sabril causes permanent vision loss in infants, children and adults.  The onset is unpredictable and can occur within weeks of starting treatment, or sooner, or at anytime during treatment even after months or years.  Because of this risk of permanent vision loss, Sabril approval is accompanied by an FDA-mandated Risk Evaluation and Mitigation Strategy (REMS) and is available only through a special restricted distribution program called SHARE (Support Help and Resources for Epilepsy)”. Link
 

This drug Vigabatrin is marketed as Sabril® in America by Lundbeck Link and in Europe by Sanofi-Aventis. Link

Suicidal ideation and behaviour have also been reported in patients treated with anti-epileptic agents including this drug, along with congenital defects  increasing 2 to 3 fold in children born from mothers treated with an antiepileptic; the most frequently reported are cleft lip, cardiovascular defects and neural tube defects.

Listed side effects are…

Common: agitation, aggression, nervousness, depression, paranoid reaction.

Uncommon: hypomania, mania, psychotic disorder

Rare: suicide attempt

Psychiatric reactions have been reported during vigabatrin therapy. These reactions occurred in patients with and without a psychiatric history and were usually reversible when vigabatrin doses were reduced or gradually discontinued.

cipramil (celexa) stories,, psychiatry, Shanes story.

Are psychiatrists just idiots in Ireland or is it a global phenomenon?

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Here is two ‘Irish College of Psychiatry’ statements regarding SSRIs and Shane’s inquest in the summer 2010 newsletter. Naturally the statements deny that suicide or homicide can be a side effect of antidepressants. Protecting their medical model once again! Keep dishing out mind altering drugs; what’s a few dead people when pills = money?

Now I know everyone is entitled to their own opinion, but surely “best practice” for doctors who have spent years studying medicine is not to bury their heads in the sand and ignore all the evidence. This is not me trying to justify what happened to Shane. This is about letting people know about the side effects of this medication (SSRIs).

I cannot tell you why psychiatry Ireland are trying so hard to suppress the mounting evidence of suicide/homicidal events relating to SSRIs but I can give you the evidence as I see it.

Summer 2010

College of psychiatry Ireland Newsletter.

 

“As communicated recently to our members, the college did not issue a detailed statement during two recent inquests where evidence linking antidepressant use with self-inflicted death and the death or injury of others was presented. We have now issued a full statement to all print and broadcast media outlining clearly our position and disquiet on the speculative nature of this evidence.

The statement is available on our website (www.irishpsychiatry.ie) and was emailed to all members. Thank you to all those involved in the whole process to compile this important piece.”

DR. Justin Brophy, President.

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CLARIFICATION ON ANTIDEPRESSANT MEDICATION.

“In the past month there has been considerable discussion in Ireland  of suicidality and homicidality as potential adverse effects of selective serotonin reuptake inhibitors (SSRI) antidepressant medication. Much of this discussion has been speculative.

Clearly, suicide and homicide are events of the utmost gravity and any possible role of any  treatment  in precipitating such tragedies warrants the most thorough investigation. However, discussion of the risks involved must be based on evidence rather than conjecture or unfound opinion.

Untreated depression can have a fatal outcome. Those experiencing moderate-to-severe depression frequently describe having thoughts of self-harm.  Antidepressants are effective in the treatment of depression. The effective treatment of depression is an important means of reducing suicide rates.

A high volume of research in recent years has failed to establish a causal link between antidepressant use and suicide. At an individual level, the period early in treatment may be a time of relatively high risk, as treatment tends to start when the person’s depression is severe and treatment takes some weeks to work. As treatment takes effect and energy and motivation return, people who have recently commenced antidepressant treatment may be more able to act on suicidal thoughts that are inherent to their condition. That the early recovery period is potentially a period of increased risk for suicidality is something of which all doctors should be aware. The college of psychiatry of Ireland, in unison with the Irish medicines board, recommend close monitoring of all individuals commenced on antidepressant therapy.

There is no evidence of a link between antidepressant use and homicide.

A more detailed statement articulating the issues is attached and available on the website of the college of psychiatry of Ireland,  http://irishpsychiatry.ie”

These are the actual facts..

1. Ssri’s with homicidal ideation  listed as an adverse reaction on patient information leaflet- paxil (canada), zoloft (canada), effexor and luvox.

2. Listed side effects on Irish patient information leaflet for cipramil.. agression, depersonalisation,hallucination, mania and reports of “thoughts of harming or killing yourself”.

3.  The FDA officially extended the age group for the black box warning about antidepressant inducing suicidal thinking and behavior from 18 to 24.

4. Irish medicines board..Informaton from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant.

5. Lundbeck letter states reports of self harm and harm to others with cipramil.

6. Irish medicines board..Under 18’s suicide related behaviours ( suicide attempt and suicidal thoughts) and hostility ( predominantly agression, oppositional behaviour).

7. The European Medicines Agency’s scientific committee concluded that all SSRI and SNRI antidepressants were associated with increased suicide-related behavior and hostility in young people.

8. The Commission of the European Communities issued the strongest warning yet against child antidepressant use as the drugs caused suicidal behaviour including suicide attempts and suicidal ideation, aggression, hostility (predominantly aggression, oppositional behavior and anger) and/or related behavior.

9.  Japan’s National Health Ministry directed pharmacy companies to revise labeling to warn that antidepressants could cause suicide.

10. Wikipedia..In the United States, citalopram, like other antidepressants, carries a black box warning stating that it may increase suicidal thinking and behaviour  in those  under age 24.

11. A recent publication of the top 31 drugs that are disproportionately linked with violent behavior.  5 in the top 10 were antidepressants.

Surprise, Surprise –11 of the 31 were antidepressants!     Cipramil (celexa) came 16th.

 

 

E-MAIL TODAY..

Excerpts from the minister for mental health’s e-mail to me today. Surprise surprise, he’s far too busy to meet up with me but I suppose I should be thankful that he finally got around to replying to my numerous e-mails!

Dear Ms Fennell

9th February 2011

“John Moloney, Minister for Disability and Mental Health has asked me to thank you for your email dated 6th January, 2011. Unfortunately, due to diary commitments, the Minister is unable to meet with you in the near future.

The letter also referred to the IMB’s Drug Safety Newsletter in late 2008, which stated that a review was undertaken at EU and US level to assess the risk of suicidality in adults treated with antidepressants. The review concluded that young adults may be at an increased risk of suicidal behaviour when treated with antidepressants.

As a result of this review, it was agreed at EU level that the product information for all antidepressants should be further updated to more fully reflect the current evidence regarding the potential risk of suicidal behaviour with antidepressants.”

Random

Alli, GSK and the Irish Medicines Board.

We were watching “operation transformation” on RTE tonight, still expecting Gerry Ryan to appear, when this advert came on about a weight loss drug Alli.

I said aloud that I thought I had read something about this drug this morning. Tony and Jack just nodded in “Yeah, yeah whatever” style.

So I did a search and this is what the Irish Medicines Board think is OK to licence. This is what RTE think is OK to advertise without the need to inform consumers of the very serious side effects. I didn’t see any of the possible adverse reactions listed on the advertisments!

Where is the Broadcasting Association of Ireland now? Not much point in being skinny if you end up on chemo or in a coffin!

Alli, Xenical, Actos and Avandia Dangerous Drugs Causing Liver Damage and Liver Failure

by Alexander Hawes on December 3, 2009

Liver failure and liver damage are being diagnosed in greater and greater numbers of people who have taken the weight loss drugs Alli and Xenical and who have had their diabetes treated with Actos or Avandia.

The liver performs many basic functions. It digests food, eliminates toxins, and makes proteins. When the liver is damaged, every system in the body suffers.

By the time a person becomes aware of liver failure, serious damage has already occurred. People suffering from liver damage may be constantly tired. Their skin may turn yellow, they may be very itchy, and they may experience swelling because their bodies cannot eliminate fluids.

Liver failure traditionally was due to cirrhosis by excessive and prolonged alcohol consumption.Of these four drugs, Alli, marketed by British pharmaceutical company GlaxoSmithKline (GSK) is the only one that consumers can buy without a prescription. Alli works by preventing some of the fat that a person consumes from being broken down and turned into calories.

The clever marketing machine behind Alli hypes the drug as the first over-the-counter (OTC) weight loss aid approved by the FDA, but the marketing doesn’t bother to shout the fact that Alli is also the first OTC medication approved by the FDA that is known to cause pre-cancerous lesions. As I have reported many times before, the FDA is a national embarrassment.

Xenical, marketed by Roche Laboratories, is actually the same drug (orlistat) as Alli. The difference is that Xenical comes in a stronger dose than Alli and requires a prescription.

The dangers of orlistat have been obvious for many years.  Public Citizen filed a petition asking the FDA to ban Xenical in 2006, and not only did the FDA ignore the evidence against the drug, but a year later it approved Alli, making it simple for everyone to buy orlistat at the nearest drug store.

Avandia, marketed by GSK, and Actos, marketed by Takeda Pharmaceuticals, are dangerous drugs that also have strong links to liver damage and liver failure, which usually follows with liver dialysis and a drastically shortened life expectancy.

Avandia and Actos are prescribed for the treatment of diabetes, and their dangers have been widely known for many years. Research previously linked Avandia to heart disease, loss of vision, and bone fractures. Liver failure is just the latest problem to surface with Avandia.

That same research found Actos to be just as toxic as Avandia. “Public Citizen’s study shows it (Actos) has liver toxicity risks similar to its relative (Avandia); 10 cases of death from Actos-related liver failure were found in the study.”

A compilation of the side-effects of Actos reported to the FDA showed that in addition to liver damage, the drug has caused a wide range of serious health problems.

Alli, Xenical, Actos, and Avandia are dangerous drugs. The FDA knows that, but it allows these poisons to remain on the market. The manufacturers know how harmful their products are, but they continue to put profits ahead of the health of their customers, and the number of personal injuries and wrongful deaths associated with these drugs continues to grow.