Random

Vigabatrin/Sabril (which can be used in infants), can cause blindness, suicide ideation and aggression.

Targeting infants now? Leave them alone!!!
 
Last week I came across a blog for pharmaceutical reps and employees, it was called Cafepharma and it allows people employed in the Pharmaceutical industry to post messages on a Message Board. Link. I thought this was an interesting answer to a query posted by a prospective employee of lundbeck…
 
Question.

What’s it like to work for Lundbeck?
Please give me the good, bad, and the ugly. And pleeeeease…no snide remarks like CP posters often give. I’ve been approached to apply for a position (a product that is for intermittent seizures in infants). Anyone have any insight about the company and/or the product’s popularity/pros and cons of promoting it?
Thanks in advance to any serious posters.
 
Answer
Vigabatrin in the product. Serious side effects like making kids go blind. You better go speak with some child neuro`s in your area to get the real info. It is an end of the line product with very limited usage due to severe side effect risks. Be very careful with this company. If you`re asking for anonymous advice, I`d stay clear of it unless you just have been unemployed for a very long time and need a pay check.
 

Vigabatrin:

 
The message board didn’t paint a pretty picture of lundbeck and subsequently I googled lundbeck’s product Vigabatrin, and sure enough it can cause irreversable blindness! It is an anti-epileptic drug that can be prescribed for intermittent seizures in infants. As far as I’m aware, you cant die from epilepsy so why would anyone prescribe this for an infant, when it’s possible that they can end up being blind as well as epileptic? Then if the child is old enough he/she might commit suicide or an act of agression, totally as a side-effect of the drug and the people that are left behind will never be informed of this! Surely there is a better alternative?
 
This is what it says on lundbeck’s own website… “Sabril causes permanent vision loss in infants, children and adults.  The onset is unpredictable and can occur within weeks of starting treatment, or sooner, or at anytime during treatment even after months or years.  Because of this risk of permanent vision loss, Sabril approval is accompanied by an FDA-mandated Risk Evaluation and Mitigation Strategy (REMS) and is available only through a special restricted distribution program called SHARE (Support Help and Resources for Epilepsy)”. Link
 

This drug Vigabatrin is marketed as Sabril® in America by Lundbeck Link and in Europe by Sanofi-Aventis. Link

Suicidal ideation and behaviour have also been reported in patients treated with anti-epileptic agents including this drug, along with congenital defects  increasing 2 to 3 fold in children born from mothers treated with an antiepileptic; the most frequently reported are cleft lip, cardiovascular defects and neural tube defects.

Listed side effects are…

Common: agitation, aggression, nervousness, depression, paranoid reaction.

Uncommon: hypomania, mania, psychotic disorder

Rare: suicide attempt

Psychiatric reactions have been reported during vigabatrin therapy. These reactions occurred in patients with and without a psychiatric history and were usually reversible when vigabatrin doses were reduced or gradually discontinued.

cipramil (celexa) stories,, lundbeck, Newspaper and internet articles, Random

India

I was on the internet today researching a young man who died in a citalopram/cipramil trial in India. His name was Dharmesh Vasava, he was 22 and died shortly after participating in a trial for citalopram. At first he was reported to be in hospital with pneumonia and on humanitarian grounds, the company (Sun pharmaceuticals Link) paid for his treatment (Their kindness is staggering). He died a few days later!

Dharmesh was a causal labourer, his mother was a sweeper in a local school, while his father worked in a textile mill on daily wages. According to another participant of the same trial, the subjects were lured with money by agents working for the company. Vasava’s brother, Mukesh, told Bharuch police that Dharmesh became a victim of negligence of the pharma company that took his blood for tests. The People’s Union of Civil Liberties, Vadodara, conducted an investigation into the death. PUCL suggested that the participants were unlikely to have been able to give their voluntary informed consent to participate.

Drug trials are going on all over the world but there seems to be a sinister trend with the amount of drug companies doing trials on the poor people of India, with the quality of these trials in some cases questionable at best. These trials have been sponsored by the big players (among others) Lundbeck, Johnson & Johnson, Pfizer, Novo Nordisk, GlaxoSmithKline, Shire, Novartis, Bayer, Merck, Sanofi Aventis and Roche.

The Business Standard reported that there were 671 deaths logged last year in drug trials in India and there is evidence that compensation was only given in 3 cases.Link. There have been questions raised about the data quality in some of these trials along with problems with corruption and scams, and presumably the same data that drug companies are using to get approval for the same drugs from the fda, the ema, the mhra and the Irish Medicines Board!

In one Indian hospital alone 49 babies died involving drug testing. Link

How is this going on in 2011? India is only half way from here to Australia, not a different planet!! Are Indian babies not worth as much as Irish babies???? Ah yes I forgot, drug trials/experiments were done on babies and children in Ireland too. Link , and Link.

Do the Irish government officials know when they are wining, dining and greeting these drug company executives off planes, that they are killing people across the globe?

Drug Trials—the Dark Side (BMJ)…Link